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| Product name | Kudzu root (Pueraria lobata) |
| Latin name | Pueraria lobata (Willd．) Ohwi |
| Synonyms | Pueraria lobata, kudzu, kudzu vine, Pueraria Lobata, Radix Puerariae, kudzuvine root |
| Active ingredient | Isoflavone （Puerarin、Daidzin、Daidzin、Genistein） |
| CAS NO | 3681-99-0、552-66-9、486-66-8、446-72-0 |
| Part used | Root |
| Specification | Kudzu root (Pueraria lobata) (40% isoflavones) ; Kudzu Root Extract (standardized for 1% daidzin) |
| Appearance | Light yellow fine powder |
| Applied industries | dietary supplements, cosmetics, food additives |
What is Kudzu root (Pueraria lobata)?
Kudzu root is a fast growing evergreen vine originated from China, and was brought to the United States from Japan in the late 1800s. You may have heard about kudzu lately. It’s gotten a lot of mainstream attention due to recent a Harvard University study on the plant’s ability to help decrease consumption of alcohol in human subjects. Although the entire plant is edible, kudzu’s health supporting benefits come primarily from its flowers and roots, which contain several natural compounds including isoflavonoids and saponins.
Chemical constituents of Kudzu Root extract
The compositions of kudzu root are various. Chemical analysis of kudzu has revealed that the herb encloses many helpful isoflavones, counting daidzein (an anti-microbial and anti-inflammatory agent), genistein (an anti-leukemic agent) and daidzin (a substance that puts off development of cancer). In addition, kudzu is also a distinct source of the isoflavone called puerarin. The chemical compounds found in kudzu root have the ability to influence neurotransmitters (counting serotonin, glutamate and GABA). Kudzu has also demonstrated its effectiveness in treating migraine as well as cluster headache.
Twenty-two compounds were isolated and characterized as beta-sitosterol palmitate , beta-sitosterol, lupeol, lupeone , puerarol, diisobutyl phthalate, bis(2-ethylhexyl) phthalate, sophoracoumestan A, coumestrol, allantion , dadzein , formononetin, 3'-methoxy daidzein , ononin , 3'-hydroxy dadzein, genistin, daidzin, 8-methoxy ononin, sissotorin, (-)-puerol B 2-O-glucopyranoside, (6S,9R)-roseoside and sucrose , respectively. Kudzu is rich in isoflavones, flavonoids, plant sterols, and glycosides.The active ingredient is Pueraria Isoflavones, Pueraria Flavonid and Puerarin.
Mechanism of action of kudzu root (Pueraria lobata)
How does kudzu root extract work? There is information that suggests kudzu contains ingredients that counteract alcohol. It might also have effects like estrogen. Chemicals in kudzu might also increase blood circulation in the heart and brain.
The applicable parts of kudzu are the root, flower, and leaf. Kudzu contains isoflavone constituents including daidzin, daidzein, puerarin, genistin and genistein. Kudzu extracts or individual isoflavones such as daidzin consistently suppress voluntary alcohol intake in rodent models of alcoholism. Kudzu extract, daidzein and daidzin decrease alcohol consumption and shorten alcohol-induced sleep in alcohol-craving animals. Preclinical research suggests kudzu root powder causes later and lower peak blood alcohol levels and a flattened dose response curve. Kudzu root powder might decrease peak blood alcohol levels due to delayed gastric emptying, exposing alcohol to a longer time for first-pass metabolism in the stomach. Slowed gastric emptying might prolong the effects of alcohol. Other research suggests kudzu root powder might have antioxidant effects and speed up the metabolism of toxic alcohol metabolites. Preliminary research suggests the kudzu constituent puerarin might lessen feelings of anxiety associated with alcohol withdrawal.
Research in animal models of stroke suggests an ethanolic extract of kudzu root can increase levels of norepinephrine and dopamine in the brain, which might improve post-stroke depression.
Isoflavone constituents have both estrogenic and antiestrogenic activity, similar to selective estrogen receptor modulators. These phytoestrogens might have additive or synergistic effects with each other.
Kudzu root powder might also have effects on the cardiovascular system. Preliminary research suggests kudzu root powder has a protective effect against myocardial ischemia. Puerarin seems to reduce both systolic and diastolic blood pressure, and diminish myocardial oxygen consumption. Puerarin also might have vasorelaxant properties, possibly by blocking beta-adrenergic receptors. There is also some evidence that puerarin might decrease plasma renin and angiotensin II activity, and platelet aggregation. The kudzu constituent daidzein might also have antiarrhythmic properties.
In ischemic stroke, puerarin might reduce ischemic reperfusion injury by dilating cerebral vessels to improve circulation, reducing platelet aggregation, inhibiting free radical production, and increasing superoxide dismutase activity.
Kudzu or its constituents might have hypoglycemic, hypocholesterolemic and antioxidant activity. Kudzu root powder also might have antipyretic effects, possibly through the effect of puerarin on serotonin receptors.
Preliminary research also suggests that kudzu and puerarin both inhibit and induce cytochrome P450 isoenzymes. However, it is unclear which CYP isoenzymes are affected and to what degree.
Benefits of taking kudzu root extract supplements
As mentioned in the above mechanism of actions, Kudzu root is regarded as beneficial to Alcohol cessation, Menopause, Metabolic syndrome, blood sugar, cholesterol, lipids, triglycerides,etc.
Kudzu root and Alcoholism
Kudzu might help treat alcohol addiction. TCM practitioners have traditionally given intoxicated people doses of kudzu root tea to help them sober up.
Heavy drinkers who took kudzu extract consumed fewer alcoholic drinks than the people who took a placebo. Those who took the kudzu also took more sips to finish their drinks. This indicates that kudzu supplements might help treat alcoholism, but more clinical studies need to verify these claims.
Kudzu root and Menopausal Symptoms
Isoflavones found in kudzu are similar to those in soy. The soy isoflavones have a known estrogenic effect, or produce results similar to the estrogen hormone, but research on the kudzu isoflavones have had mixed results. Human subjects who consume kudzu extract report a reduction in the number of hot flashes they suffer each day. The Memorial Sloan-Kettering Cancer Center notes that consuming kudzu might alleviate some menopausal symptoms, particularly hot flashes and night sweats. Consult your doctor before using kudzu supplements to treat menopausal symptoms.
Kudzu root and Cardiovascular Health
Kudzu root may also help to promote cardiovascular system health in a variety of ways. The isoflavones found in kudzu reduce high cholesterol levels, lower high blood pressure and help to prevent the blood from becoming sticky, clumping together and forming blood clots. In addition, kudzu extracts help to dilate blood vessels and increase oxygen and blood flow to the heart and brain, and kudzu is sometimes used to treat angina.
Side effects of taking kudzu root supplements
Pueraria lobata root is not recommended to be used by pregnant and breastfeeding women. Although the use of this herb is considered safe it is still better to be safe than sorry when it comes to side effects. The use of Pueraria lobata root as a treatment for your illness must be consulted first with your doctor or herbal specialist. Ask for your appropriate dose and about whether there are any possible adverse reactions to the medicines you may be taking currently. Be safe when using herbal remedies and buy only from reputable sources.
Dosage of taking Kudzu root supplement
The appropriate dose of kudzu depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for kudzu. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.