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| Product name | Citrus Aurantium Powder Extract |
| Botanical Name | Citrus Aurantium |
| Ingredients | Hesperidin |
| Synonyms | Cirantin, Hesperidine, Hesperidoside, Hesper bitabs, Hesperetin-rutinosid，Citrus bioflavonoid |
| Appearance | Fine orange or slighty yellow crystalline powder |
| Part used | Rinds |
| Specification | Hesperidin 90%,95%,98% HPLC |
| Dosage | 50mg-150mg twice daily |
| Main benefits | Varicose Veins, Hemorrhoids, Lymphedema |
| Applied industries | Prescription Medicine, Supplements |
What is Hesperidin
Hesperidin is a flavonoid found in the rinds of citrus fruits, which is one of the flavonoids that give citrus fruits their color and taste. Along with the compound rutin, hesperidin is the most active bioflavonoid in citrus based fruits. The hesperidin bioflavonoid helps protect your body from conditions like cancer, circulatory problems and heart disease. As a citrus bioflavonoid, hesperidin facilitates the formation of vitamin C complex, which supports healthy immune system functions.
Hesperidin is also referred to by names like bioflavonoid, citrus bioflavonoid, and hesperin methyl-chalcone. It is often present in multi-vitamins, though it can also be found as a pure extract. You can get hesperidin in certain foods or as a dietary supplement. While hesperidin and other similar bioflavonoids are commonly referred to as vitamin P, they are not actual vitamins. Hesperidin does not naturally occur in the body; you can only get it through foods or synthetic supplements. Before using a hesperidin supplement, consult your physician to determine its safety for your health conditions.
Hesperidin and Diosmin
According to Dr Oz, Hesperidin is a flavonoid found in citrus fruits that helps Varicose Veins. Dr Oz also said to look for a Hesperidin pill with Dismoin and take 500 mg daily. So you may wonder the relations between Hesperidin and Diosmin, and maybe you will understand after you read the following:
Diosmin is derived from hesperidin, which originates in citrus plants and belongs to the flavonoid group of substances. Researchers believe that hesperidin and diosmin interfere with arachidonic acid metabolism and histamine release. Pharmaceutical manufacturers commonly combine both hesperidin and diosmin into one formulation as a phlebotropic drug, meaning the substance benefits vascular structure. Companies partially convert hesperidin to diosmin and sell a combination that usually contain 90% diosmin and 10% hesperidin. While these formulations require a prescription in parts of Europe, hesperidin and diosmin retail as dietary supplements in other parts of the world.
How Hesperidin Works
Abnormally high blood pressure in the veins causes fluid leakage into the surrounding tissues. The accumulating tissue fluid must be returned to the circulation through the lymphatic system. In chronic venous insufficiency, the lymphatic system becomes overloaded, leading to tissue swelling, or edema. A subsequent inflammatory response involving white blood cells causes deterioration of blood vessel integrity and vessel swelling, which further increases fluid leakage from the veins. The hesperidin plus diosmin complex inhibits inflammatory processes and reduces fluid loss into surrounding tissues. These flavonoids also stimulate lymphatic function and the return of tissue fluid back into the blood circulation, thereby reducing edema.
What are the Benefits of taking Hesperidin?
Along with the compound rutin, hesperidin is the most active bioflavonoid in citrus based fruits. Hesperidin alone, or in combination with other citrus bioflavonoids (diosmin, for example), is most often used for blood vessel conditions such as hemorrhoids, varicose veins, and poor circulation (venous stasis). It is also used to treat lymphedema, a condition involving fluid retention that can be a complication of breast cancer surgery.
Hesperidin for Varicose Veins
When it comes to, Hesperidin has proven to be most effective on varicose veins because it acts as an anti-inflammatory agent which also diminishes the permeability of capillaries. Hesperidin has its greatest utility as a treatment for varicose veins when it is combined with other bioflavonoids such as Diosmin along with other natural varicose vein fighters.
Supplements containing a combination of hesperidin, extract of the herb butcher's broom, and ascorbic acid (a form of vitamin C) may help treat chronic venous insufficiency, according to a 2007 study published in International Angiology.
The study involved 124 people with chronic venous insufficiency. Every day for eight weeks, all study members took two capsules of the hespiridin/butcher's broom/ascorbic acid formula. Starting in the second week of the study, participants showed significant improvements in their symptoms (including pain, cramps, and swelling). The study's authors suggest that the hespiridin/butcher's broom/ascorbic acid may help treat chronic venous insufficiency by producing beneficial effects in patients' blood vessels. Hesperidin for Hemorrhoids
In a 1994 study, a supplement containing a combination of hespiridin and diosmin was found to aid in the treatment of hemorrhoids. For the study, 100 patients suffering from a hemorrhoid attack were treated with either the hespiridin/diosmin combination or a placebo for seven days. Compared to the placebo group, members of the supplement group showed significantly greater improvement in symptoms.
More recent research on the use of hespiridin in treatment of hemorrhoids is lacking.
Hesperidin for Lymphedema
Hesperidin plus diosmin supplementation has been shown to help reduce lymphedema in the arms following breast cancer surgery.
Hesperidin plus diosmin acts on the lymphatic system by increasing lymph flow and lymph oncotic pressure. A flavonoid mixture containing hesperidin plus diosmin was used to treat upper limb lymphedema secondary to conventional therapy for breast cancer. Results showed improvement of symptoms and limb volume; the mean decrease in volume of the swollen limb reached 6.8 percent. In addition, lymphatic functional parameters assessed with scintigraphy were significantly improved. Animal studies of high-protein lymphedema, such as in burns and lung contusions, showed significant improvement with hesperidin plus diosmin.
Dosages of Hesperidin
The combination of hesperidin and other bioflavonoids, such as diosmin, helps alleviate hemorrhoids and chronic venous insufficiency. Hesperidin is also useful, along with the compound naringin, as a potential treatment for preventing the progression of hypoglycemia, according to a 2004 study in the "Journal of Nutrition."
For the treatment of hemorrhoids inside the anus: 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days.
For preventing the return of hemorrhoids inside the anus: 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months.
For the treatment of leg ulcers caused by poor blood circulation (venous stasis ulcers): a combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months.
Side effects of Taking Hesperidin
Hesperidin is likely safe when used orally for less than a year. However, it may be unsafe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers).
According to the researchers, common side effects associated with oral use of Hesperidin include nausea, diarrhea, abdominal cramps, and vomiting. Rare but serious side effects associated with internal Hesperidin may also include tightness of the chest, skin rash, difficulty breathing, hives, itching, swelling or tingling of the mouth, and swelling of the hands or face.
Therefore, it's important to consult your physician if any of these side effects are experienced, then immediate medical attention should be sought.
In addition, hesperidin may be unsafe for people with blood disorders.