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| Product name | Progesterone |
| Synonyms | progesterone cream,P4, pregn-4-ene-3,20-dione,Pregnancy Hormone,Progesterona |
| CAS Number | 57-83-0 |
| Molecular Formula | C21H30O2 |
| Molecular Weight | 314.51 |
| Specification | 99% |
| Appearance | White or almost white crystalline powder |
| Solubility | Practically insoluble in water, freely soluble in ethanol, sparingly soluble in acetone and in fatty oils. |
| Loss on drying | NMT 0.5% |
What is Progesterone?
Progesterone, according to Wikipedia, is a female steroid hormone manufactured by the corpus luteum of the ovary at ovulation and is a precursor to most of the other steroid hormones, including cortisol, androstenedione, the estrogens and testosterone.
Progesterone and pregnancy
Progesterone is a natural female hormone. Called “the pregnancy hormone,” it is essential before and during pregnancy. Progesterone is essential to achieving and maintaining a pregnancy, prepares the uterus for pregnancy, and also supports the embryo.
How Progesterone works?
A key ingredient to a healthy pregnancy, progesterone production increases after ovulation and continues to be produced at these higher levels for about a month if a pregnancy occurs. This helps to build a strong uterine lining for the embryo to grow. If fertilization did not occur following ovulation, then progesterone production will cease, triggering the body to release the uterine lining through the normal menstrual flow.
If for some reasons the body either makes too little progesterone (or too much) during this time, ovulation may be hindered and/or a fertilized egg will not be able to survive in the environment it is released into.
A lot of things can cause an unusual fluctuation of progesterone in the body: too much estrogen; pollution; eating hormone-fed animals (and their by-products); or even eating too much soy.
Benefits of taking progesterone supplements and drugs
Progesterone is the “mother of all hormones”. It is the raw material from which your body makes all other hormones.
A summary of the many roles of progesterone follows:
1Promotes bone building and protects against osteoporosis
2.Improves premenstrual symptoms (PMS)
3.Protects against endometrial cancer
4.Helps protect against breast cancer
5.Precursor of other sex hormones (estrogen and testosterone) and cortisone
6.Maintains lining of uterus
7.Promotes survival of the embryo and fetus throughout gestation
8.Natural diuretic
9.Promotes fat burning for energy (thermogenesis)
10.Acts as a natural antidepressant
11.Aids thyroid hormone action
12.Normalizes blood clotting
13.May help maintain sex drive
14.Helps keep blood sugar levels normal
15.Normalizes zinc and copper levels
16.Promotes proper cellular oxygen level
Side effects of taking progesterone
Women with too much progesterone in their bodies usually experience these common symptoms: anxiety, low libido, allergy-like symptoms, sore breasts, irregular periods, early onset of menstrual cycle, fatigue and tiredness, insomnia, weight gain, trouble concentrating/general fogginess, headaches, hair loss, etc
Dosage of taking progesterone supplement:
The following doses have been studied in scientific research:
BY MOUTH:
•For hormone replacement therapy: 200 mg micronized progesterone (Prometrium) per day is typically taken for 12 days of a 25-day cycle with 0.625 mg conjugated estrogens.
APPLIED TO THE SKIN:
•For hot flashes and other symptoms of menopause: 20 mg progesterone cream (equivalent to 1/4 teaspoon Progest cream) is typically applied daily to rotating places on the body including upper arms, thighs, or breasts.
INSIDE THE VAGINA:
•For breast pain associated with noncancerous breast disease: a typical dose of 4 grams of vaginal cream containing 2.5% natural progesterone is placed inside the vagina from the 19th to the 25th day of a 28-day cycle.
•For restoring menstrual periods in women who have not reached menopause: one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina every other day for 6 days per month.
•For hormone replacement therapy, one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina on days 17, 19, 21, 23, 25, and 27 of a 28-day cycle with 0.625 mg conjugated equine estrogens.
•For reducing vaginal bleeding and reversing the thickening of the lining of the uterus in premenopausal women with noncancerous endometrial hyperplasia: a dose of 100 mg progesterone cream placed inside the vagina daily from day 10 to day 25 of a 28-day cycle has been used.