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4-AndrostenedioneMG8Shanghai Natural Bio-engineering Co., Ltd

CAS:63-05-8MG8Shanghai Natural Bio-engineering Co., Ltd

Molecular Formula: C19H26O2MG8Shanghai Natural Bio-engineering Co., Ltd

Molecular weight: 286.4MG8Shanghai Natural Bio-engineering Co., Ltd

What is 4-Androstenedione?

4-Androstenedione, popularly known as Androstenedione or 4-AD, has many other names. The synonyms of 4-Androstenedione include 17-ketoestosterone, Andro, Androstene, Androst-4-ene-3,17-dione, 4-Androstene-3,17-dione, 4-Androstenedione, Androtex, 63-05-8, 3,17-Dioxoandrost-4-ene, Fecundin, 4-AD,SKF 2170 etc. If you are not sure whether it is 4-Androstenedione, make sure that there is only one CAS number for it, and it is 63-05-8.MG8Shanghai Natural Bio-engineering Co., Ltd

According to Wikipedia, 4-Androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the oestrogens oestrone and oestradiol. 4-Androstenedione originates either from the conversion of dehydroepiandrosterone (DHEA) or from 17- hydroxyprogesterone. Conversion of dehydroepiandrosterone to androstenedione requires 3-ß-hydroxysteroid dehydrogenase. 17- hydroxyprogesterone, on the other hand, requires 17, 20 lyase for its synthesis. Thus, both reactions that produce androstenedione directly or indirectly depend on 17, 20 lyase. 4-Androstenedione is further converted to either testosterone or oestrogen. Conversion of 4-androstenedione to testosterone requires the enzyme 17ßhydroxysteroid dehydrogenase, while conversion of androstenedione to oestrogen (e.g. oestrone and oestradiol) requires the enzyme aromatase. The production of adrenal androstenedione is governed by ACTH(Adrenocorticotropic Hormone), whereas production of gonadal androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total androstendioneMG8Shanghai Natural Bio-engineering Co., Ltd

Anabolic steroids are commonly utilized to treat people who have a hormone deficiency or who have muscle wasting due to cancer or HIV. They have also been utilized as performance enhancing drugs to increase muscle strength and size for competitive sports. Supplements containing androstenedione were introduced in the mid 1990’s and were promoted as a natural way to help increase strength and muscle mass and to combat the effects of the aging process in older men, much of which is attributed to declining testosterone levels. Like DHEA, androstenedione is a naturally derived precursor to testosterone. Androstenedione converts directly to testosterone in the metabolic pathway. The fact that it is naturally derived and, as described below present in the food supply, is important in relation to the action taken by FDA.MG8Shanghai Natural Bio-engineering Co., Ltd

How 4-Androstenedione works (mechanism of action)

Androstenedione is an androgenic hormone produced naturally in men and women that's converted by the liver into testosterone. It's produced in the adrenal glands and gonads by DHEA (dehydroepiandrosterone) or 17-a-hydroxyprogesterone for those technical gurus. In essence, androstenedione is a mere single step away (that is, one metabolic reaction in the body) from testosterone.MG8Shanghai Natural Bio-engineering Co., Ltd

So from this, the assumption has been made that when androstenedione is ingested, it readily converts to testosterone, and when combined with physical exercise, the direct result is muscular growth. But, it's not that simple. You see, androstenedione's effects on human muscle growth are still "up in the air" in the scientific community since no studies to date have revealed direct positive effects. Although there does appear to be a definite surge of testosterone in the blood when androstenedione is supplemented before a workout, which may lead to more "aggressive" weight-training sessions, potentially resulting in increased muscle growth.MG8Shanghai Natural Bio-engineering Co., Ltd

The theory was that if additional androstenedione were introduced, the body would treat it like it occurs naturally. This leads to abnormally high testosterone levels because the ingested andro serves as a manufactured, inactive precursor to testosterone. Males produce testosterone—an anabolic sex hormone—in large quantities. The resulting spike in testosterone upon its direct conversion from andro should enhance the adaptations of resistance and strength training athletes.MG8Shanghai Natural Bio-engineering Co., Ltd

Benefits of taking 4-Androstenedione supplements

According to the mechanism of action above, we know how 4-Androstenedione works, and the benefits are obvious as below:MG8Shanghai Natural Bio-engineering Co., Ltd

It Increases Lean Muscle Mass.MG8Shanghai Natural Bio-engineering Co., Ltd

It Increases Strength & Endurance.MG8Shanghai Natural Bio-engineering Co., Ltd

It Improves Muscle Recovery.MG8Shanghai Natural Bio-engineering Co., Ltd

It Improves Protein Synthesis & Nitrogen Retention.MG8Shanghai Natural Bio-engineering Co., Ltd

It Increases Libido (Sex Drive).MG8Shanghai Natural Bio-engineering Co., Ltd

It Elevates Testosterone Levels, Androstenedione is the no. 1 muscle building supplement in the world.MG8Shanghai Natural Bio-engineering Co., Ltd

Side effects of taking 4-Androstenedione supplements

4-Androstenedione can have androgenic side effects that include acne, scalp hair loss, facial hair growth in women, aggressiveness, and irritability. Chronic use can also raise levels of estrogen, something that could lead to enlarged breasts and an increased risk of certain types of cancer. Prostate enlargement could be a concern in older men. Long-term side effects with regular use for months or years are currently not fully known.MG8Shanghai Natural Bio-engineering Co., Ltd

What is the effective dosage of Androstenedione?

Dietary supplement dosages of androstenedione range from 5 to over 50mg per day in the morning or 60 minutes before working out. Experts suggest the best way to take andro is by cycling it. The proper cycle is six weeks of taking it followed by two weeks off. However, it's in your best interest to take an equally long off period, or even longer off period. This gives your natural systems a chance to recover. Supplement manufacturers claimed that a dosage of 60mg to 300mg, depending on the supplement, would be necessary to elicit a testosterone increase of 100% or greaterMG8Shanghai Natural Bio-engineering Co., Ltd

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