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 zQeShanghai Natural Bio-engineering Co., Ltd

Product Name Polydatin 98% piceid (Polygonum cuspidatum)
Other names Piceid, Resveratrol 3-beta-mono-D-glucoside, Reservatrol-3-β-mono-D-glucoside, Resveratrol 3-O-β-D-glucopyranoside
Botanical Source Polygonum cuspidatum Sieb. et Zucc
CAS Number 65914-17-2
Appearance White to off-white crystalline powder
Molecular Formula  C20H22O8
Molecular weight 390.38
Specifications 95% HPLC, 98% polydatin
Solubility Soluble in water (<1 mg/ml at 25 °C), DMSO (78 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), methanol, and ethyl acetate
Long Term Storage Store at 4° C
Benefits Anti-aging, Anti-Cancer, cardiovascular support, regulate estrogen level, weight loss

What is Polydatin?

Polydatin, also known as piceid, is a glucoside of resveratrol, which means that the resveratrol is joined to a sugar molecule. It seems that in scientific documentations, scientists prefer to using piceid, while in supplements or daily life, polydatin is more popular. Therefore, we will use polydatin more often in the rest of the article.zQeShanghai Natural Bio-engineering Co., Ltd

Once the polydatin enters the bloodstream the sugar molecule is cleaved off, leaving the resveratrol. This in turn means that the glucoside of resveratrol is absorbed at a different rate to standard trans-resveratrol, thereby effectively increasing the half-life and the potency of the resveratrol.zQeShanghai Natural Bio-engineering Co., Ltd

Botanical source of polydatin extract

Polydatin, according to Wikipedia introduction, is a stilbenoid glucoside and is a major resveratrol derivative originally found in grape juices. It can be found in the bark of Picea sitchensis. It can also be isolated from Polygonum cuspidatum, the Japanese knotweed (syn. Fallopia japonica). In modern mass production of polydatin extract and resveratrol 98%, polygonum cuspidatum is the main source for extracting high quality polydatin as high as 98%. It is high in polydatin, and cost is relatively low compared with other soures.zQeShanghai Natural Bio-engineering Co., Ltd

Like resveratrol, there are two kind of polydatin as well, cis-polydatin and trans-polydatin. Trans-polydatin is what active in the combination of the Polygonum cuspidatum. zQeShanghai Natural Bio-engineering Co., Ltd

Polydatin VS Resveratrol

Resveratrol can be produced from polydatin fermented by Aspergillus oryzae. That’s why people call polydatin as the precursor of resveratrol.  This latter species produces a piceid-b-D-glucosidase.zQeShanghai Natural Bio-engineering Co., Ltd

Trans-piceid is the glucoside formed with trans-resveratrol, while cis-piceid is formed with cis-resveratrol. Trans-resveratrol-3-O-glucuronide is one of the two metabolites of trans-piceid in rat.zQeShanghai Natural Bio-engineering Co., Ltd

Polydatin conversion to Resveratrol

When polydatin is consumed in powder or wine form it gets converted to resveratrol and reaches the blood stream. Polydatin allows resveratrol to skip phase I metabolism and enter into the blood stream more readily.zQeShanghai Natural Bio-engineering Co., Ltd

Polydatin and Resveratrol Plasma Levels

We have learned from various animal studies that the amount of resveratrol plasma from polydatin is over 3 times that of taking pure resveratrol. This percent difference is about 105%. Polydatin also gives resveratrol a longer half life of 107mins (dosed at 50mg/kg). Pure resveratrol has a half life of 15-20mins. When scientists dosed at 300mg/kg of polydatin the half life of resveratrol was 425minszQeShanghai Natural Bio-engineering Co., Ltd

Therefore, polydatin has been shown to be superior to resveratrol by two orders of magnitude in certain applications.zQeShanghai Natural Bio-engineering Co., Ltd

For that matter, speaking of resveratrol analogues, polydatin is promising and available if you know where to look.  Some Japanese researchers have reported on its metabolites, and it results in high blood levels of resveratrol, higher than one gets by taking resveratrol.  It seems to bypass intestinal glucoronidation and first pass liver metabolism, giving quite a spike.zQeShanghai Natural Bio-engineering Co., Ltd

The market of resveratrol fluctuates up and down with the international demand changes, while polydatin is not. Polydatin is a specific ingredient intensively researched based on Chinese Traditional Medical theories in China,zQeShanghai Natural Bio-engineering Co., Ltd

Since 1970s and 1980s, Chinese scientists have begun to research Polydatin. According to President Liu, President of Hunan Keyuan Bio-products co., Ltd, the Second Military Medical University and other new medicines research centers are in the process of 3rd clinical trials for Polydatin. However, R&D of medicine is a long period, and the future is uncertain. So, at present, Polydatin is still a nonmainstream product both on domestic and international markets. Lacking the support of international scientific research, it is really hard for Polydatin developing on international market .As we know, Polydatin has begun to export in small quantity since ten years ago, but until now, there is no marked increase in export. However, resveratrol is world-wide known since 2006, and the demand is even among TOP 20 of China’s herbal extract export ranking.zQeShanghai Natural Bio-engineering Co., Ltd

 Polydatin is a single active ingredient, directly extracted from Huzhang. The international market generally demands 98%+ Polydatin, while 90% Polydatin on domestic market. Hydrolyzing aglucones of Polydatin, we will get Resveratrol. It is to say, Polydatin is the precursor of Resveratrol. zQeShanghai Natural Bio-engineering Co., Ltd

When Resveratrol rose to fame, Polydatin didn’t. On the contrary, the hot of Resveratrol brought high pressure to the poor market of Polydatin .As it is known to the earliest professionals of Resveratrol, in fact, the development of Resveratrol is young compared with Polydatin .It is just because of the demand pull on international market, that it becomes hot. In the earliest, when Harvard researchers declared the shocking information—Resveratrol can activate human longevity genes, what they used in research is Resveratrol extracted from grape peels. Following it, many research centers began to be keen on Resveratrol and the Resveratrol supplements were expecting to develop .As the low content of Resveratrol in grape peels, the production cost is very high. Therefore, Polydatin was exploited to be the substitute of Resveratrol. The whole world is familiar with Resveratrol, and some may know Huzhang, but a few people know Polydatin.zQeShanghai Natural Bio-engineering Co., Ltd

In fact, the hydrolysis, or name as solubility of Polydatin is better than Resveratrol and it has stronger effects on metabolism and hereditation as reported. According to our supplements brands clients, the international market demands higher level on Resveratrol’s hydrolysis, Millirod dosage form and other performances, in order to improve its usability rate. It is quite possible that, Polydatin will attract more attention from international research centers.zQeShanghai Natural Bio-engineering Co., Ltd

Mechanism of action of polydatin

How does polydatin work? Polydatin has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. Myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels. Polydatin preconditioning (PPC) has been reported to be protective against brain and intestine ischemia/reperfusion injury. It also exerts cardioprotective effect by the activation of PKC-K(ATP)-dependent signaling and the direct anti-oxidative stress mechanisms. Polydatin affects lipopolysaccharide‘s induction on VEC ICAM-1;Polydatin affects the neutrophils’s chemotaxis reaction inspired by lipopolysaccharide; Polydatin affectsmooth muscle and Cardiomyocytes PKC under the situation of ischemia, hypoxia, burn serum, and LPS; Polydatin was used in treating severe Acute Pancreatitis in the early stage; Polydatin affects TLR4 when reducing the injury occurred during perfusing blood to ischemic Rabbit lung; Experiments and researches both in vitro and in vivo on of Polydatin curing Viral Myocarditis.zQeShanghai Natural Bio-engineering Co., Ltd

Benefits of taking polydatin extract supplements

Polydatin has all the benefits that resveratrol has, such as Anti-aging, Anti-Cancer, cardiovascular support, regulate estrogen level, weight loss.zQeShanghai Natural Bio-engineering Co., Ltd

Main Functions of polydatin are list as below:

1.Polydatin can used to anticancer;zQeShanghai Natural Bio-engineering Co., Ltd

2.Polydatin has effect on cardiovascular system;zQeShanghai Natural Bio-engineering Co., Ltd

3.Polydatin own the nourishing and protecting liver;zQeShanghai Natural Bio-engineering Co., Ltd

4.Polydatin has the useage of antibacterial and antifungal;zQeShanghai Natural Bio-engineering Co., Ltd

5.Polydatin has impact on the metabolism of osseous issue;zQeShanghai Natural Bio-engineering Co., Ltd

6.Polydatin own the effective of ntioxidant and quench free-radicals.zQeShanghai Natural Bio-engineering Co., Ltd

 However, polydatin has many advantages above trans-resvetatrol.zQeShanghai Natural Bio-engineering Co., Ltd

One advantage of polydatin over trans-resveratrol is that the metabolites of polydatin are up to 1,000 times more concentrated in the tissues of animals than are in the same metabolites of resveratrol.zQeShanghai Natural Bio-engineering Co., Ltd

Where to buy high quality natural polydatin extract?

Hunan Keyuan Bio-products Co., Ltd is a professional raw material manufacturer of herbal extracts in China, and the key products are resveratrol and resveratrol analogs, and resveratrol derivatives. Polydatin is one of our most popular products. The buyers will have easy access to a reliable source of high quality polydatin as well as extensive technical advice on these compounds. zQeShanghai Natural Bio-engineering Co., Ltd

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