Grape seed extract, from the introduction of Wikipedia, is industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid and phenolic procyanidins (also known as OPC or oligomeric procyanidins). The typical commercial opportunity of extracting grape seed constituents has been for chemicals known as polyphenols having antioxidant activity in vitro.

 

Grape seed extract is a complex mixture of flavonoids composed of 73.32 to 77.63% oligomeric and polymeric flavan-3-01s (proanthocyanidins) and less than 5.5% monomeric flavan-3-01s (catechins) (dry weight basis).  Proanthocyanidins have been identified in various foods including chocolate, wine, fruits such as apples, cherries and plums, fruit juices, beans, and tea.

 

Grape Seed Extract contains the below ingredients:

•Proanthocyanidins (also known as procyanidins), polymers of catechin (subset of flavonoids) molecules at around 74-78% by weight and sometimes up to 81% of Grape Seed Extract

•Specific procyanidin molecules such as Procyanidin B1 (5.3%), B2 (3.1%), and C1 (1.7%) (different formations of catechin couplets)

•Free flavonol esters such as epicatechin and catechin (two of the Green Tea Catechins) at less than 6%

How does grape seed grape work? Grape Seed Extract (GSE) has been implicated in reducing adipocyte differentiation, similar to many plant-derived polyphenols. 

 

Polyphenols, part of a broad class of bioflavonoids, are commonly found in grape seeds. One type of polyphenols known as proanthocyanidins is highly regarded for their strong antioxidant properties, and for their functions in supporting the body’s connective tissues and capillary blood vessel system. Proanthocyanidins are among the most powerful natural free-radical scavengers yet discovered. As such, proanthocyanidins have their own unique place in the body’s overall protection against harmful free radical damage. Proanthocyanidins appear to be especially effective in neutralizing highly reactive hydroxyl and singlet oxygen radicals. Both of these reactive oxygen species are involved in inflammatory processes. Proanthocyanidins also support and enhance the activity of vitamin C, and are known for their ability to help support the health of the body's capillary system and connective tissues. Proanthocyanidins have been shown to bind with collagen fibers, thereby protecting them from premature degradation. This helps maintain the natural elasticity of collagen in skin, joints, arteries, capillaries, and other connective tissues.

 

Today’s polluted environment exposes your body to increasing challenge from free radicals. In nature, proanthocynidins are the pigments that impart blue, purple, and red hues to plants. Red grapes are chock-full of health-giving proanthocyanidins, but we discard the most valuable part: the seeds. While nutritional science continues to find ever more benefits for proanthocyanidins, they are especially renowned for supporting the health of blood vessels. Research is ongoing into the use of grape seeds to support the health of eyes, skin, arteries and capillaries, and to maintain cholesterol levels already in the normal range.

 

Grape seed extract appears to exert its anti-inflammatory effects in fat cells, which has been noted in adult differentiated adipocutes. Despite acting partially similar to insulin (as an insulin mimetic, but on different post-translational pathways). Increased glucose uptake into fat cells has been observed in response to Grape seed extract.

A very general inhibitory action on lipases (enzymes that hydrolyze triglycerides into free fatty acids) exists, and this applies to lipoprotein lipase (LPL) which brings fats into a cell. Inhibition of LPL appears to be the mechanism underlying protection of grape seed extract against lipotoxicity,  and its efficacy has been noted to be 2% inhibition at 0.1mg/mL 30% inhibition at 1mg/mL in vitro; these concentrations are much higher than normally observed in vivo after oral administration of grape seed extract.

Grape Seed Extract (Vitis vinifera) (95% Polyphenols )

Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)

Grape Seed Extract (seed) standardized concentrate of Vitis vinifera (seed) containing 95% procyanidolic value.

Grape Seed extract delivering 95% antioxidants from 65% Oligomeric Procyanidins (OPCs) and 30% other active polyphenols

Grape Seed extract (Vitis vinifera) 100:1

Grape Seed Extract (Proanthodyn) With a Procyanidolic Value of 95

Grapeseed Extract 400 mg **

(Vitis vinifera) (seed)

  (Standardized to contain 50% polyphenols) 

There are a plenty of health benefits for grape seed extract (Vitis vinifera) (95% Polyphenols  OPC), such as lower blood pressure, support blood vessels, etc. There’s strong evidence that grape seed extract is beneficial for a number of cardiovascular conditions. Grape seed extract may help with a type of poor circulation (chronic venous insufficiency) and high cholesterol. Grape seed extract also reduces swelling caused by injury and helps with eye disease related to diabetes.

It''s the polyphenols in grape seeds that make them a highly potent antioxidants and protect the the body against oxidative and free radical damage. Scientific studies show that the antioxidant power of grape seed extract is 20 times more powerful than vitamin E and 50 times greater than vitamin C.

Helps maintain blood pressure already within the normal range

Earlier grape seed extract research has shown that this natural extract can activate the production of friendly nitric oxide (eNOS) by turning on the enzyme (nitric oxide synthase) that helps to make it. This causes a relaxing effect in the arteries, helping blood flow more easily. 

Grape seed extract helps to strengthen blood vessels, by increasing the tone and elasticity of capillary walls. Results from human case reports and animal studies show that grape seed extract may be useful to treat heart diseases, such as high blood pressure and high cholesterol. Grape seed extract slows down the oxidation of the fats that responsible for cholesterol. The longer it takes for fats to oxidize, the less likely they will clog up your veins and arteries.

 

Grape seed extract provides potent protection for the capillaries—tiny blood vessels that play a vital role in the cardiovascular system. In human and animal studies, grape seed extract has been found to support capillary resistance and prevent capillary permeability.

 

Capillaries are often viewed merely as links between our arteries and veins. But it is through the capillary walls that oxygen and nutrients in the bloodstream are carried to your tissues and wastes are removed, allowing cells to live. Capillaries consist of a single cell layer reinforced with strands of collagen. The material that fills the spaces between capillary walls also consists largely of collagen. Proanthocyanidins protect collagen against free radical damage. They also protect against enzymes that damage collagen and elastin.

Proanthocyanidins also benefit the cardiovascular system by preventing lipid peroxidation(oxidation of fats). There is a growing body of research which suggests that preventing the oxidation of LDL (bad) cholesterol is at leastas important to heart health as maintaining normal cholesterol levels. 

Proanthocyanidins have been associated with supporting normal visual function. In one study of 100 volunteers, grape seed extract was found to support visual performance by ensuring nourishment of the retinal structures.